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Pedro Neira Pelén

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Articles

Host–virus determinants of Ebola virus persistence in a human cerebral organoid model

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By Lina Widerspick, Santiago Freire, Julia Nave, Stephanie Wurr, Dennis Tappe, Lisa Oestereich, Jonas I. Müller, Angelique Hoelzemer, Thomas Hoenen, Nicole Kleinstreuer, Ian Crozier, Gabriella Worwa, Jens H. Kuhn, Gustavo Palacios, César Muñoz-Fontela, Johanna F. Steffen, Shruti Shirsathe, Petra Allartz, Molly A. Vickers, Christoph Henkel, Pedro Neira Pelén, Monika Rottstegge, Michelle Heung, Leonore Mensching, John G. Bernbaum
| Nature Verified
Abstract Ebola virus (EBOV) causes Ebola virus disease (EVD), a multisystemic human disease associated with an extraordinarily high case-fatality rate. EVD survivors may experience recrudescent inflammation with viral persistence in immune-privileged tissues, including the central nervous system (CNS). Persistence, defined by ongoing replication of the EBOV genome beyond the acute disease phase, may lead to virion production. Productive persistence has been linked to re-initiation of EVD outbreaks.
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