Pehr Rissler on Muck Rack

Pehr Rissler

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Articles

Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors

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By Jenny Maria Nilsson, Linda Magnusson, Nils Hansen, Karim H. Saba, Thoas Fioretos, Pehr Rissler, Karolin H. Nord
| Color Research & Application Verified
Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors.
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