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Pei-Ying Li

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Articles

Maternal obesity disrupts epigenetic reprogramming via peroxisomal-dependent phospholipid-methyl uncoupling during zygotic genome activation

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By Lin-Li Yang, Xie Feng, Yu-Wei Zhang, Lei Guo, Sun-Xing Huang, Tie-Gang Meng, Pei-Ying Li, Lei-Ning Chen, Rui-Bao Su, Jun-Yu Ma, Xiao-yan Fan, Jia-Li Su, Yue-fan Wang, Qing-Yuan Sun, Xiang-Hong Ou, Xiao-Guohui Zhang, Lan-Fang Luo, Ng-Shyh Chang, Shi-Ming Luo
| Nature Verified
Abstract Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here we show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes and downregulates PEX13, impairing peroxisomal protein import in 2-cell embryos.
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Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trial - Cell Discovery

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By Fang-Rong Yan, Amar Sharma, Wei-Feng Yu, Bo Zhai, Pei-Ying Li, He-Xin Yan
| Nature Verified
Abstract Liver transplantation remains constrained by the scarcity of donor organs and the risks inherent in the procedure, underscoring the urgent need for novel cirrhosis therapies. We developed a protocol to convert human primary hepatocytes into expandable hepatocyte-derived liver progenitor-like cells (HepLPCs), which secrete high levels of matrix metalloproteinases and hepatocyte growth factor.
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