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Peidi Yin on Muck Rack

Peidi Yin

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Articles

Enhanced FOS expression improves tumor clearance and resists exhaustion in NR4A3-deficient CAR T cells under chronic antigen exposure

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By Haiyang Luo, Pingping Li, Clàudia Rodés-Bachs, Peidi Yin
| Science Magazine Verified
Abstract The dysfunction of chimeric antigen receptor (CAR) T cells in the tumor microenvironment is a major obstacle to their therapeutic efficacy against solid tumors. Through single-cell RNA sequencing analysis of tumor-infiltrating T cells from patients with glioma, NR4A family genes were identified as closely associated with T cell exhaustion and were coexpressed with dysfunctional genes HAVCR2 and TIGIT.
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