Peihuang Wu on Muck Rack

Peihuang Wu

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Articles

Chidamide synergizes with cisplatin-etoposide to trigger pyroptosis and anti-tumor immunity in diffuse large B-cell lymphoma

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By Jianbo Wu, Yingying Ye, Danyang Ran, Xing Wang, Hanwen Zhu, Hanmei Zhang, Fuqing Meng, Yalong Song, Zhiwei Li, Xiaoyuan Zhang, Yixin Qian, Hanrong Li, Xiaowei Tong, Bowen Sun, Xinya Li, Weimin Zhang, Huajun Wu, Yingjie Yu, Yunkun Dang, Fan Lai, Lijuan Deng, Yuqin Song, Jun Zhu, Yan Xie, Mi Deng, Peihuang Wu
| Nature Verified
Abstract Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy where many patients relapse after standard therapy, necessitating novel approaches. Pyroptosis is an inflammatory cell death that can stimulate antitumor immunity. Histone deacetylases are frequently overexpressed in DLBCL and contribute to immune evasion. This study investigates whether combining the HDAC inhibitor chidamide with cisplatin and etoposide induces pyroptosis and enhances antitumor immune responses.
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