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Peik Sean Chong on Muck Rack

Peik Sean Chong

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Articles

Gene regulatory network analysis identifies auranofin as an anti-atherosclerotic drug

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By Letizia Amadori, Claudia Calcagno, Ravneet Kaur, Hauke Horstmann, Tianshe He, Michael A. Gildea, Ken Sakurai, Roza Shamailova, Christopher Hill, Swathy Sajja, Raphael Soler, Christopher M. Faries, Edward Fisher, Zahi A. Fayad, Nathanael Fillmore, Jaime Ramos-Cejudo, Benjamin Readhead, Joel T. Dudley, Johan L. M. Björkegren, Chiara Giannarelli, Peik Sean Chong, Sonum Naidu, Jordan Bresciani, Maxwell La Forest, Adam A. Ghotbi
| Nature Verified
Abstract Gene-regulatory networks (GRNs) offer a mechanistic framework for dissecting the complex molecular and genetic architecture of coronary artery disease and for identifying new therapeutic opportunities. Here, we present a GRN-driven drug-repurposing strategy that integrates transcriptional signatures induced by silencing key drivers of the human arterial wall foam cell regulator GRN 42 with drug-induced gene expression profiles from the NIH LINCS program.
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