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Articles

Hot “Dissolving” Extrusion of Lurasidone with Natural Liquid Small Molecule for Amorphous Solid Dispersion Based Self‐Assembled Submicron Emulsion

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By Peiya Shen, Chunfeng Zhang, Yuan Gao Verified, Enshi Hu
| pericles.pericles-prod.literatumonline.com
Nowadays, about 90% of new drug candidates under development are poorly bioavailable due to their low solubility and/or permeability.
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Incorporation of Complexation into a Coamorphous System Dramatically Enhances Dissolution and Eliminates Gelation of Amorphous Lurasidone Hydrochloride

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By Weili Heng, Meiling Su, Peiya Shen, Shujun Liang
| American Chemical Society
As a BCS II drug, the atypical antipsychotic agent lurasidone hydrochloride (LH) has low oral bioavailability mainly because of its poor aqueous solubility/dissolution. Unexpectedly, amorphous LH exhibited a much lower dissolution than that of its stable crystalline form arising from its gelation during the dissolution process.
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