Peiyan Yu

Abstract Objective: This single-center, real-world study exploratorily compared early PSA kinetics between apalutamide plus androgen deprivation therapy (ADT) and triplet therapy (ADT, apalutamide, and docetaxel). Methods: This study was designed as a single-center retrospective cohort study. A total of 36 patients with newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC) and adverse prognostic features between January 2022 and September 2024 were included.

1 Introduction Bacterial trapping offers a promising strategy to combat antibiotic resistance by targeting mechanisms that help bacteria evade antibiotics, such as internalization in host cells or escaping areas with high local drug concentrations.[1-6] Human-defensin 6 (HD6) peptide forms an effective bacteria-trapping nanonet in the human small intestine,[7, 8] but recreating such nanonet using short synthetic peptides is challenging due to the limited understanding of the design principles.