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Predominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials
PURPOSE: To describe predominantly persistent intraretinal fluid (PP-IRF) and its association with visual acuity (VA) and retinal anatomic findings at long-term follow-up in eyes treated with pro re nata (PRN) ranibizumab or bevacizumab for neovascular age-related macular degeneration. DESIGN: Cohort within a randomized clinical trial. PARTICIPANTS: Participants in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT) assigned to PRN treatment.
Thiazolidinedione Use and Retinal Fluid in the Comparison of Age-Related Macular Degeneration Treatments Trials
BACKGROUND: Thiazolidinediones, commonly used antidiabetic medications, have been associated with an increased risk of development of diabetic macular oedema and increased vascular endothelial cell permeability. Macular neovascularisation in age-related macular degeneration (AMD) and associated fluid leakage may be influenced by thiazolidinediones.
Prediction for Two-Year Vision Outcomes Using Early Morphological and Functional Responses in the Comparison of AMD Treatments Trials (CATT)
To predict 2-year visual acuity (VA) responses to anti-vascular endothelial growth factor (anti-VEGF) therapy using early morphological and functional responses in patients with neovascular age-related macular degeneration (nAMD). 1185 participants with untreated active nAMD and best corrected VA (BCVA) 20/25 to 20/320 at baseline. Secondary analysis of data from participants randomized to either ranibizumab or bevacizumab and to one of three dosing regimens.
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