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Population Pharmacokinetic Modeling and Exposure-Response Analysis for the Antibody-Drug Conjugate Enfortumab Vedotin in Locally Advanced or Metastatic Urothelial Carcinoma - Zuo - Clinical Pharmacology & Therapeutics - Wiley Online Library
WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Enfortumab vedotin is a fully human, Nectin-4-directed monoclonal antibody conjugated to monomethyl auristatin E. In a phase 3 study in patients with locally advanced or metastatic urothelial carcinoma who previously received platinum-based chemotherapy and a programmed cell death protein 1/ligand 1 inhibitor, enfortumab vedotin 1.25 mg/kg (days 1, 8, and 15 of a 28-day cycle) was associated with significantly longer overall survival vs.
Effects of early adversity on the brain: Larger-volume anterior cingulate cortex in AIDS orphans
Loading metrics Open Access Peer-reviewed Research Article Peiying Zuo , Yinan Wang , Jia Liu, Siyuan Hu, Guoxiang Zhao, Lijie Huang, Danhua Lin Peiying Zuo, Yinan Wang, Jia Liu, Siyuan Hu, Guoxiang Zhao, Lijie Huang, Danhua Lin Published: January 14, 2019 https://doi.org/10.1371/journal.pone.0210489 Figures Abstract Multiple studies have revealed that adolescent AIDS orphans have more psychosocial problems than healthy adolescents.
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