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Pellis-van Berkel

As seen in: Nature
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Articles

It takes two to tango: NAD+ and sirtuins in aging/longevity control

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By Shin-ichiro Imai, Leonard Guarente, Pellis-van Berkel
| Nature Verified
Abstract The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a mechanistic foundation that translates the regulation of energy metabolism into aging and longevity control in diverse organisms.
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