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Pengcui Li on Muck Rack

Pengcui Li

As seen in: Nature, Frontiers, MDPI, Taylor & Francis Online, Dove Medical Press, Swiss Medical Weekly
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Articles

Age-related degeneration initiates at the surface: preferential biomechanical and biological decline in rat articular cartilage

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By Yuanyu Zhang, Ningning Ma, Gaige Wu, Yukun Yin, Ruxing Liu, Jingrui Huang, Chunfang Wang, Li Guo, Xiaochun Wei, Pengcui Li, Dahai Rong, Raorao Zhou
| Nature Verified
Abstract Age-related degeneration of articular cartilage is a key pathological hallmark of primary osteoarthritis (OA). As the cartilage’s barrier layer, the superficial zone maintains tissue homeostasis and is increasingly recognized as the initial site of age-related cartilage degeneration. Disruption of this zone exposes deeper layers to hostile microenvironments, accelerating pan-cartilaginous changes; however, its age-related progression remains incompletely defined.
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A new device and method for detecting the permeability of articular cartilage

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By Fuyang Cao, Haibin Deng, Guohao Zhang, Ningning Ma, Xianda Che, Pengcui Li, Li Guo, Xiaochun Wei, Binghang Zhang, Gaige Wu
| Frontiers
Abstract Objective: Articular cartilage relies on synovial fluid for substance exchange, with permeability being a key parameter linked to its physiological functions and degenerative disease mechanisms. Existing detection techniques are limited by detachment from physiological mechanical environments, insufficient quantification accuracy, and poor sealing. This study aimed to develop an accurate, reliable, and physiologically relevant device and method for cartilage permeability detection.
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Histone deacetylase 4 in limb mesenchyme is essential for chondrocyte proliferation, growth plate maintenance and proper bone formation

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By Yunfei Wang, Ling Wu, Sujing Zong, Pengcui Li
| Taylor & Francis Online
ABSTRACT Background Dysregulation of well-ordered chondrocyte proliferation and differentiation leads to distorted architecture of the growth plate, resulting in skeletal dysplasia with impaired longitudinal bone growth. Histone deacetylase 4 (HDAC4) is essential for chondrocyte hypertrophy and endochondral bone formation, but its role in postnatal bone development remains unexplored due to early lethality in Hdac4-ablated mice.
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