Pengfei Hai

As illustrated in Fig. 1a, SIR-PAM uses a series of PISFs with different spatial frequencies and phases to stimulate PA signals within an object. By using the phase-shifting method and resolving the depth based on time-of-flight information carried by PA signals, we can extract the Fourier spectrum of the optical absorption distribution at each depth with a single-element ultrasonic transducer. Then, a volumetric PA image with SIR is reconstructed.

The goal of breast-conserving surgery is to completely remove all of the cancer. Currently, no intraoperative tools can microscopically analyze the entire lumpectomy specimen, which results in 20 to 60% of patients undergoing second surgeries to achieve clear margins. To address this critical need, we have laid the foundation for the development of a device that could allow accurate intraoperative margin assessment.