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AARS1 promotes tumor progression and immune evasion via ATF6 lactylation-mediated tryptophan metabolism in hepatocellular carcinoma

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By Yiming Wang, Fan Li, Jiongyuan Li, Tianning Huang, Tian Huang, Nan Zhang Verified, Yiran Li, Ziyu Xun, Zhe Zhu, Qiaorui Tan, Xuanyu Zhao, Mingjian Piao, Chengjie Li, Boyu Sun, Jingwen Ma, Pengyao Chen, Jian Gu, Shipeng Dai, Hao Wang, Ming Ni, Haitao Zhao, Ling Lu, Liangwei Zou
| Cell Metabolism Verified
Single-cell transcriptomic sequencing and data analysis Sample collection The immunotherapy-related HCC cohort included seven pre-treatment baseline biopsies and six post-immunotherapy surgical specimens, all used for downstream single-cell transcriptomic sequencing and analysis. Specimens were collected at Peking Union Medical College Hospital (PUMCH), Beijing, China, with approval from the PUMCH Ethics Committee (I-24PJ0611).
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