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Penille Jensen

As seen in: BioRxiv
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Articles

Dietary fibre promotes chronic whipworm infection through direct and time-dependent modulation of innate immunity

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By Laura J. Myhill, Pankaj Arora, Anne Jensen, Penille Jensen
| BioRxiv
Abstract Dietary fibre regulates the microbiome and gut health but increases murine whipworm (Trichuris muris) infection through unclear mechanisms. We show that mice fed inulin-supplemented diets exhibit dysregulated innate antimicrobial defences and altered tryptophan metabolism during T. muris infection. Inhibiting tryptophan catabolism or neutralizing IL-27 and IL-18 in inulin-fed mice restored infection resistance. Notably, inulin led to chronic infection even in microbiota-depleted mice.
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