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Penninga EI

As seen in: Association of Anaesthetists
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Articles

Routine flumazenil administration and the interpretation of a non-inferiority comparison: a reply

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By Byung-Moon Choi, Sim JH, Penninga EI
| Association of Anaesthetists
Deng and Peng [1] question whether routine flumazenil administration confounded our comparison of remimazolam and propofol [2]. The authors' concern rests on the premise that flumazenil-induced central nervous system hyperexcitability could have influenced our delirium assessments. This is difficult to reconcile with either the pharmacokinetics of flumazenil or the timing of our measurements.
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