Per thor Straten on Muck Rack

Per thor Straten

As seen in: Nature, Frontiers
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Articles

The evolving role of cytokines for CAR-T cell manufacturing and beyond

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By Johanna Nimmerfroh, Dominic Schwarz, Jessica Hartmann, Christian D. Klein, Heinz Läubli, Michal Lotem, Christophe Paget, Sine Reker Hadrup, Per thor Straten, Sebastian Theurich, Dario Venetz, Alfred Zippelius, Laurence Zitvogel, Sebastian Kobold, Mar Guaza-Lasheras, Tanja D. de Grujil, Joerg Mittelstaet, Sonja Schallenberg
| Nature Verified
Abstract Chimeric antigen receptor (CAR)-T cells represent a recent clinically validated modality in cancer therapy and beyond. However, broad industrial implementation faces technological, logistical, regulatory and financial challenges. A major bottleneck is the ex vivo production process, where cytokines are essential and product-determining constituents.
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Frontiers | Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice

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By Alejandro López-Soto, Zohreh Amoozgar, Per thor Straten
| Frontiers
Helena Batatinha1,2†, Douglass M. Diak1,2†, Grace M. Niemiro2,3, Forrest L. Baker1,3, Kyle A. Smith1, Tiffany M. Zúñiga1, Preteesh L. Mylabathula1, Michael D. Seckeler2, Branden Lau4, Emily C. LaVoy5, Michael P. Gustafson6, Emmanuel Katsanis2,3,7 and Richard J.
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