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Pere Pericot-Masdevall on Muck Rack

Pere Pericot-Masdevall

As seen in: BioRxiv
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Articles

Allele imbalance in mRNA is selected in tumorigenesis, results from epigenetic alterations and has prognostic relevance

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By Guillermo Palou-Márquez, Pere Pericot-Masdevall, Fran Supek, Biotech Research
| BioRxiv
Abstract Allelic imbalance (AI) in levels of mRNAs that originated from the paternal and maternal copies of a gene can contribute to phenotypic variation and influence disease traits, including cancer. It is widely appreciated that AI at the DNA level, resulting from somatic copy number alterations (CNA) in tumors, generates second-hit events by which tumor suppressor genes are inactivated and oncogenes are activated; the somatic CNAs are also a known cause of AI at the mRNA level.
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Allele-specific expression is selected in tumorigenesis, results from epigenetic changes and has prognostic relevance

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By Guillermo Palou-Márquez, Fran Supek, Biotech Research, Pere Pericot-Masdevall
| BioRxiv
Abstract Allele-specific expression (ASE) is the differential abundance in levels of mRNAs that originated from the paternal and maternal copies of a gene. Such allelic imbalances can contribute to phenotypic variation and influence disease traits, including cancer.
Open in Who Shared Issue with article?
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