Andrea Schubert

Abstract Controlled signaling activity is vital for normal tissue homeostasis and oncogenic signaling activation facilitates tumorigenesis. Here we use single-cell transcriptomics to investigate the effects of pro-proliferative signaling on epithelial homeostasis using the Drosophila follicle cell lineage. Notably, EGFR-Ras overactivation induces cell cycle defects by activating the transcription factors Pointed and E2f1 and impedes differentiation.

INTRODUCTION The alveolar bone is a specialized tissue of the mandibula and maxilla, surrounding the teeth and forming the tooth sockets [1]. Healthy alveolar bone hosts osteocytes, osteoblasts, and osteoclasts that are embedded in a vascularized calcified extracellular matrix (ECM) that mostly consists of osteocalcin, osteopontin, and collagen types I, III, V, and VI [2-4].