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Articles

Co-administration of toll-like receptor (TLR)-3 and 4 ligands augments immune response to Newcastle disease virus (NDV) vaccine in chicken

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By ICAR-Directorate, T. R. Kannaki, E. Priyanka, M. R. Reddy
| link.springer.com
Original Article First Online: 24 August 2019 Abstract Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that mediate first line of host defence to pathogens. TLR agonists are potent immunostimulatory agents that help to prime a robust adaptive immune response. In the present study, adjuvant potential of Poly I:C and lipopolysaccharide (LPS) were evaluated with live Newcastle disease virus (NDV) vaccine.
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Conformational analysis of a synthetic fish kisspeptin 1 peptide in membrane mimicking environments

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By Atul Singh Verified, Dimpal Thakuria, ICAR-Directorate, Neetu Shahi
| PLOS
Kisspeptin 1 is a neuropeptide hormone of the RFamide family, which act as an upstream regulator of brain-pituitary-gonad (BPG) axis in most vertebrates including teleosts. In the present study, a 16 amino acid long putative mature bioactive peptide (kiss 1) from preprokisspeptin 1 of golden mahseer, Tor putitora (Hamilton, 1822), was synthesized and characterized using an integrated (experimental and in silico) approach.
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