Peter JM Valk on Muck Rack

Peter JM Valk

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Articles

Prognostic impact of myelodysplasia-related gene mutations in FLT3-ITD-mutated acute myeloid leukemia - Leukemia

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By Rabea Mecklenbrauck, Ángela Villaverde Ramiro, Javier Martinez Elicegui, Maria Teresa Voso, Alberto Hernández-Sánchez, Jesse M. Tettero, Klaus H. Metzeler, Guadalupe Oñate, Felicitas Thol, Florian H. Heidel, Peter JM Valk, Kenneth Mills, Hartmut Döhner, Gastone Castellani, Jesús María Hernández-Rivas, Lars Bullinger
| Nature Verified
Abstract The inclusion of nine myelodysplasia-related gene (MRG) mutations (ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1, ZRSR2) as adverse risk factors in the ELN risk classification has reshaped classification in acute myeloid leukemia (AML). AML with FLT3-ITD mutations and co-occurring MRG alterations is now classified to the ELN adverse risk group although supporting evidence remains limited.
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Unravelling co-mutational patterns with prognostic implications in NPM1 mutated adult acute myeloid leukemia – a HARMONY study - Leukemia

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By Alberto Hernández-Sánchez, Ángela Villaverde Ramiro, Amin T. Turki, Jurjen Versluis, Javier Martinez Elicegui, Gastone Castellani, Jesse M. Tettero, Joaquín Martínez-López, Ken Mills, Guillermo Sanz, Maria Teresa Voso, Christoph Röllig, Christian Thiede, Klaus H. Metzeler, Konstanze Döhner, Michael Heuser, Torsten Haferlach, Brian J. Huntly, Hartmut Döhner, Raúl Azibeiro, Rabea Mecklenbrauck, Peter JM Valk, Jesús María Hernández-Rivas
| Nature Verified
Abstract NPM1-mutated (NPM1-mut) acute myeloid leukemia (AML) is generally associated with a more favorable outcome, although the presence of additional gene mutations can influence patient prognosis. We analyzed intensively-treated adult NPM1-mut AML patients included in the HARMONY Alliance database.
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