peter regan

The people behind the wheel: Peter Regan’s story, Sydney Metro Can you tell us a bit about your role at Sydney Metro? As Chief Executive, I lead the procurement, construction, delivery and operations of Sydney Metro, Australia’s biggest public transport project. Sydney Metro is the biggest programme of urban rail infrastructure investment in Australian history.

Abstract The steady accumulation of senescent cells with aging creates tissue environments that aid cancer evolution. Aging cell states are highly heterogeneous. 'Deep senescent' cells rely on healthy mitochondria to fuel a strong proinflammatory secretome, including cytokines, growth and transforming signals.

Abstract The steady accumulation of senescent cells with aging creates tissue environments that aid cancer evolution. The secretome of senescent cells promotes chronic inflammation, contains growth and transforming signals, and causes chronic oxidative stress. The latter is primarily due to dysfunctional mitochondria often seen in senescent cells. Aging cell states are highly heterogeneous. 'Deep senescent' cells rely on healthy mitochondria to fuel a strong proinflammatory secretome.