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Articles by Peter Rusert
Rare twin cysteine residues in the HIV1 envelope variable region 1 link to neutralization escape and breadth development
Rare twin cysteine residues in the HIV1 envelope variable region 1 link to neutralization escape and breadth development
Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development
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Keywords HIV vaccine envelope glycoprotein broadly neutralizing antibodies elite neutralizers V1V2 Env stabilization Introduction Genetic traits of the HIV-1 envelope glycoprotein (Env) that link to bnAb development and escape in untreated HIV-1 infection are key to vaccine immunogen development.
By Maria C. Hesselman, Marius Zeeb, Peter Rusert, Chloé Pasin, Jennifer L. Mamrosh, Samuel Kariuki, Ian Pichler, Michèle E Sickmann, Masako M. Kaufmann, Daniel Schmidt, Nikolas Friedrich, Karin J. Metzner, Audrey Rindler, Herbert Kuster, Craig Adams, Ruwayhida Thebus, Michael Huber, Sabine Yerly, Karoline Leuzinger, Matthieu Perreau, Roger Koller, Günter Dollenmaier, Simona Frigerio, Dylan Westfall, Wenjie Deng, Allan C. deCamp, Michal Juraska, Srilatha Edupuganti, Nyaradzo Mgodi, Hugh Murrell, Nigel J. Garrett, Kshitij Wagh, James Mullins, Carolyn Williamson, Penny Moore, Huldrych F. Günthard, Roger Kouyos, Alexandra Trkola
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Cell Host & Microbe
Verified
The XbnAb Cohort: 304 people with broadly neutralizing antibody activity to HIV-1
Abstract Broadly neutralizing antibodies (bnAbs) recognizing a diversity of HIV-1 strains are widely thought to be essential for an HIV-1 vaccine. Extensive knowledge on bnAbs has been gained from studying natural HIV infection by following bnAb evolution in individual people with HIV (PWH). However, it remains essential to increase knowledge of bnAb responses in large PWH cohorts to assess the feasibility of inducing bnAb activity by vaccination.
Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development
New Results Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development Maria C Hesselman, Marius Zeeb, Peter Rusert, Chloé Pasin, Jennifer Mamrosh, Samuel Kariuki, Michèle Sickmann, Masako M Kaufmann, Daniel Schmidt, Nikolas Friedrich, Karin J Metzner, Audrey Rindler, Herbert Kuster, Craig Adams, Ruwayhida Thebus, Michael Huber, Sabine Yerly, Karoline Leuzinger, Matthieu Perreau, Roger Koller, Günter Dollenmaier, Simona Frigerio,...
Decoupling HIV-1 antiretroviral drug inhibition from plasma antibody activity to evaluate broadly neutralizing antibody therapeutics and vaccines
Keywords HIV-1 neutralizing antibody antiretroviral therapy Introduction Current antiretroviral therapy (ART) is highly effective in suppressing HIV-1 replication to undetectable levels,1,2 reversing CD4+ T cell decline,3,4 and reducing disease-related morbidity and mortality.5,6,7 As a result, the life expectancy of people with HIV (PWH) treated early in the infection has extended to nearly that of people without HIV.8,9,10 Typically, ART is provided as a combination therapy of drugs...
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