Skip To Main Content
Peter Sennhenn on Muck Rack

Peter Sennhenn

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile
Back to Peter Sennhenn’s profile

Articles by Peter Sennhenn

A genetic platform to deconvolve efficacy and toxicity reveals the on-target effects of CDK11 inhibition in vivo

|
By Linda Julian, Lisa Crozier, Devon A. Lukow, Aditi Swamy, Sanat Mishra, Ryan Hagenson, Erin L. Sausville, Amy J. S. McGeoch, Sarah Thompson, Brianna E. Mendelson, Lu Qiao, Anand Vasudevan, Kuan-Ting Lin, Sonam Bhatia, Thierry Bertomeu, Andrew Chatr-aryamontri, Li Zhang, Matthew Rees, Melissa Ronan, Jennifer Roth, Timothy Nottoli, Suxia Bai, Jayalakshmi Lakshmipathi, Viswanathan Muthusamy, Jonathan G. Van Vranken, Gregory Gauthier-Coles, Steven Gygi, Joan Smith, Kendall Anderson, Sanjana Shah, Ranjit Bindra, Martin Akerman, David Spector Verified, Basil J. Greber, Adrian R. Krainer, Jason M. Sheltzer, Peter Sennhenn, Claudio Chuaqui
| Nature Verified
Abstract The cyclin-dependent kinase CDK11 is an understudied kinase that has been the subject of conflicting reports regarding its function in cancer. Here, we combine genetic and pharmacological approaches to demonstrate that CDK11 is a critical regulator of cancer cell survival that is required for RNA splicing and the expression of homologous recombination genes.
Open in Who Shared Issue with article?
Show More