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Articles by Petra Steinacker
Limited Passive Diffusion of Apolipoprotein E Across the Human Blood–CSF Barrier: Evidence From Paired CSF/Serum Quotients
ApoE Apolipoprotein E BBB blood–brain barrier BCSFB brain-cerebrospinal fluid barrier CI confidence interval CLEIA chemiluminescent enzyme immunoassay CNS central nervous system CSF cerebrospinal fluid E2/E3/E4 isoform E2/E3/E4 of Apolipoprotein E FDR false discovery rate IQR interquartile range OLS Ordinary least squares Q Alb CSF/serum albumin quotient Q X CSF/serum quotient of a protein “X” RRID Research Resource Identifier (see scicrunch.org) 1 Introduction Apolipoprotein E (ApoE) is the...
Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer’s disease from amyotrophic lateral sclerosis
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Abstract Blood phosphorylated tau 217 (p-tau217) accurately detects Alzheimer’s disease (AD) pathology but is also elevated in amyotrophic lateral sclerosis (ALS), likely reflecting peripheral (big) tau released from muscle. Assays selectively measuring brain-derived (BD-) tau and BD-p-tau217 are therefore needed.
By Samir Abu-Rumeileh, Henning Großkopf, Alexander Mensch, Antonia Ratti, Julian Conrad, Caroline Stapf, Patrick Oeckl, Gisela Stoltenburg-Didinger, Alessio Maranzano, Petra Steinacker, Christopher M Weise, Lorenzo Barba, Lucio D’Anna, Hans-Wolfgang Klafki, Jens Wiltfang, Vincenzo Silani, Lutz Froelich, Nicola Ticozzi, Lucrezia Hausner, Dietmar Rudolf Thal, Ingolf Lachmann, Federico Verde, Markus Otto, Arthur Guthknecht, Dirk Osterloh, Julia Krippner, Jochen Hans Weishaupt
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Nature
Verified
Aquaporin-4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders
1 Introduction Narcolepsy type 1 (NT1) is a rare neuroimmunological sleeping disorder [1]. The disease is characterized by an autoimmune-mediated destruction of hypocretin-1 (hcrt-1) producing neurons in the hypothalamus [2] leading to the cardinal symptoms of excessive daytime sleepiness and cataplexy. Decreased cerebrospinal fluid (CSF) hcrt-1 levels are currently the only available fluid biomarker for the diagnosis of NT1 apart from clinical and polysomnographic findings [3].
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis
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Keywords ferroptosis GPX4 Alzheimer’s disease neurodegeneration cell death neuroinflammation spondylometaphyseal dysplasia Sedaghatian type SSMD Introduction The progressive loss of neurons is a recurring feature of neurodegenerative diseases, a diverse group of disorders characterized by cognitive decline, motor impairment, and, in many cases, premature death.1,2,3,4 Although neuronal death is a shared endpoint, each neurodegenerative condition presents with distinct pathological hallmarks,...
By Svenja Lorenz Verified, Adam Wahida, Mark J. Bostock, Tobias Seibt, Anastasia Levkina, Dietrich Trümbach, Mohamed Soudy, David Emler, Nicola Rothammer, Marcel S. Woo, Jana K. Sonner, Mariia Novikova, Bernhard Henkelmann, Maceler Aldrovandi, Daniel F. Kaemena, Eikan Mishima, Perrine Vermonden, Zhi Zong, Deng Cheng, Toshitaka Nakamura, Junya Ito, Sebastian Doll, Bettina Proneth, Erika Bürkle, Francesca Rizzollo, Abril Escamilla Ayala, Valeria Napolitano, Marta Kolonko-Adamska, Stefan Gaussmann, Juliane Merl-Pham, Stefanie Hauck, Anna Pertek, Tanja Orschmann, Emily Van San, Tom Vanden Berghe, Daniela Hass, Adriano Maida, Joris M. Frenz, Lohans Pedrera, Amalia M. Dolga, Markus Kraiger, Helmut Fuchs, Gregor Ebert, Jerica Lenberg, Jennifer Friedman, Patrizia Agostinis, Annemarie Zimprich, Daniela Vogt-Weisenhorn, Lillian Garrett, Sabine M. Hölter, Wolfgang Wurst, Enrico Glaab, Jan Lewerenz, Bastian Popper, Christian Sieben Verified, Petra Steinacker, Hans Zischka, Ana J. García-Sáez, Anna Tietze, Sanath Kumar Ramesh, Scott Ayton, Michelle Vincendeau, Manuel A. Friese, Kristen Wigby, Michael Sattler, Matthias Mann, Irina Ingold, Ashok Kumar Jayavelu, Grzegorz M. Popowicz, Marcus Conrad
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Cell Press
Verified
Aquaporin-4 as an early cerebrospinal fluid biomarker of Alzheimer's disease
Ms. Gomez de San Jose has no disclosures to report Dr. Halbgebauer has no disclosures to report Prof.
Longitudinal course of neurofilament light chain levels in amyotrophic lateral sclerosis-insights from a completed randomized controlled trial with rasagiline - Witzel - European Journal of Neurology - Wiley Online Library
INTRODUCTION Inhibiting MAO-B rasagiline reduces dopamine and serotonin catabolism, thereby increasing dopamine and serotonin availability for neurotransmission. In amyotrophic lateral sclerosis (ALS), prominent pathological involvement of dopaminergic [1, 2] and serotonergic neurons [3, 4] has been described. Moreover, rasagiline also possesses antiapoptotic and antioxidative properties [5-7], which could contribute to ALS pathogenesis [8].
CSF levels of SNAP-25 are increased early in Creutzfeldt-Jakob and Alzheimer’s disease
Steffen Halbgebauer1, http://orcid.org/0000-0001-6697-6522Petra Steinacker1,2, Sophie Hengge1, http://orcid.org/0000-0002-7652-7023Patrick Oeckl1,3, http://orcid.org/0000-0003-0631-8506Samir Abu Rumeileh1,2, Sarah Anderl-Straub1, Jolina Lombardi1, Christine A F Von Arnim1,4, Armin Giese5, Albert C Ludolph1,3, http://orcid.org/0000-0003-4273-4267Markus Otto1,2 1Department of Neurology, University of Ulm, Ulm, Germany 2Neurology, Martin-Luther-Universitat Halle-Wittenberg, Halle, Germany...
Blood β-Synuclein and Neurofilament Light Chain During the Course of Prion Disease
Blood β-Synuclein and Neurofilament Light Chain During the Course of Prion Disease Steffen Halbgebauer, Samir Abu-Rumeileh, Patrick Oeckl, Petra Steinacker, Francesco Roselli, Diana Wiesner, Angela Mammana, Michael Beekes, Izaro Kortazar-Zubizarreta, Guiomar Perez de Nanclares, Sabina Capellari, Armin Giese, Joaquin Castilla, Albert C. Ludolph, Dana Žáková, Piero Parchi, Markus Otto Neurology Apr 2022, 98 (14) e1434-e1445; DOI: 10.1212/WNL.0000000000200002
Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer’s disease
Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer’s disease Steffen Halbgebauer1, http://orcid.org/0000-0002-7652-7023Patrick Oeckl1, http://orcid.org/0000-0001-6697-6522Petra Steinacker1, Deniz Yilmazer-Hanke2, Sarah Anderl-Straub1, Christine von Arnim1, Lutz Froelich3, Luis Aragão Gomes4, Lucrezia Hausner3, Andre Huss1, Holger Jahn5, http://orcid.org/0000-0002-3399-9784Jochen Weishaupt1, Albert C Ludolph1, Dietmar R Thal4,6,7,...
Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia with C9orf72 hexanucleotide repeat expansion
Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia with C9orf72 hexanucleotide repeat expansion Peggy Barschke1, Patrick Öckl1, Petra Steinacker1, MHD Rami Al Shweiki1, http://orcid.org/0000-0002-3399-9784Jochen H Weishaupt1, G Bernhard Landwehrmeyer1, Sarah Anderl-Straub1, Patrick Weydt2, Janine Diehl-Schmid3, Adrian Danek4, Johannes Kornhuber5, Matthias L Schroeter6,7, Johannes Prudlo8, Holger Jahn9, Klaus Fassbender10, Martin Lauer11,...
Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis
Methods This single-centre, prospective, longitudinal study included the following patients: 124 patients with ALS; 50 patients without neurodegenerative diseases; 44 patients with conditions included in the differential diagnosis of ALS (disease controls); 65 patients with other neurodegenerative diseases (20 with frontotemporal dementia, 20 with Alzheimer’s disease, 19 with Parkinson’s disease, 6 with Creutzfeldt-Jakob disease (CJD)).
Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase
Results CSF levels of CHIT1, YKL-40 and GFAP were unaffected in asymptomatic mutation carriers (n=16). CHIT1 and YKL-40 were increased in gALS (p<0.001, n=65) whereas GFAP was not affected. Patients with ALS carrying a CHIT1 polymorphism had lower CHIT1 concentrations in CSF (−80%) whereas this polymorphism had no influence on disease severity. In gFTD (n=23), increased YKL-40 and GFAP were observed (p<0.05), whereas CHIT1 was nearly not affected.
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