Pharmaco Epidemiology

LETTER TO THE EDITOR Response to: Is the Most Likely Value Also the Best Imputation?

DNA and its properties are examples of high-dimensional data having substantial dependencies between features. In this study, we used DNA methylation data as one example of high-dimensional datasets with correlated features to investigate its impact on FDR control. For this, we use both simulated and real-world methylation array data. Methylation arrays have remained a popular technology for assaying genome-wide DNA methylation patterns.

Key Points Question Are longitudinal antidepressant fill trajectories during pregnancy associated with postpartum psychiatric outcomes? Findings In this cohort study of 57 934 pregnancies and 4 antidepressant fill trajectory groups in Denmark and Norway, early discontinuation and late discontinuation (short-term use) of antidepressants during pregnancy were associated with a decrease in initiating psycholeptics and having psychiatric emergencies post partum.