Phebe Warren

Abstract Neurons in basolateral amygdala (BLA) encode positive and negative valence. However, many additional variables must be represented to describe all aspects of emotional states. To investigate how BLA encodes these states, we presented mice with conditioned stimuli that elicited two behavioral responses: tremble and ingress into a burrow, reflecting fear and flight to safety, respectively.

Abstract Sensory stimuli associated with aversive outcomes cause multiple behavioral responses related to an animal's evolving emotional state, but neural mechanisms underlying these processes remain unclear. Here aversive stimuli were presented to mice, eliciting two responses reflecting fear and flight to safety: tremble and ingress into a virtual burrow.

Abstract Sensory stimuli associated with aversive outcomes can cause multiple behavioral responses related to an animal's evolving emotional state. We employed chemogenetic inactivation and two-photon imaging to reveal how the basolateral amygdala (BLA) mediates these state changes. Mice were presented stimuli in a virtual burrow, causing two responses reflecting fear and flight to safety: tremble and ingress into the burrow.