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Pheck Khee Lau on Muck Rack

Pheck Khee Lau

As seen in: Taylor & Francis Online, BioRxiv
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Articles

Choline intake during pregnancy influences maternal cognitive function and hippocampal gene expression in late adulthood

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By lee lim, Jingtao Zhang, Ayumu Tashiro, Pheck Khee Lau
| Taylor & Francis Online
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. ABSTRACT Background and objective Women are twice as likely to have Alzheimer's disease (AD) than men and multiparity has been suggested to be a risk factor for dementia.
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Impact of Choline intake during pregnancy on maternal cognition and hippocampal gene signature in old age

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By lee lim, Jingtao Zhang, Pheck Khee Lau, Ayumu Tashiro
| BioRxiv
Abstract Women are twice as likely to have Alzheimer disease (AD) than men and multiparity has been suggested to be a risk factor for dementia. The present study evaluated whether the lack of certain nutrients during pregnancy influences cognition while pregnant and in old age in mouse model. Non-targeted NMR analysis revealed significantly lower levels of numerous plasma nutrients and metabolites including choline and its derivatives on gestation day 7 compared to day 1.
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Omics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cells

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By Natasa Bajalovic, Pheck Khee Lau, Kye Siong Leong, Simra Hanan
| BioRxiv
Abstract The role of progesterone receptor (PR) in breast cancer remains controversial with conflicting reports from clinical and laboratory studies. To address these discrepancies, we conducted an integrated omics analysis of effects of agonist-activated PR in MCF-7 cells with elevated PR expression. PR agonist R5020 exerted strong antiproliferative and proapoptotic effects in these cells.
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