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Phil Alexander Köster on Muck Rack

Phil Alexander Köster

As seen in: BioRxiv
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Articles

Biophysics of sodium channels during subthreshold depolarization in vitro and in silico

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By Phil Alexander Köster, Thomas Stiehl, Jenny Tigerholm, Anna Maxion
| BioRxiv
Abstract Voltage-gated sodium channels (VGSC) are responsible for the fast upstroke of an action potential (AP). In the peripheral nervous system, e.g., in sensory neurons responsible for detection of potentially painful stimuli, subthreshold depolarizations support the initiation of an AP. Nav1.7 was suggested to be a subthreshold channel, and recent studies from human cells assign it a role as threshold channel.
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