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Articles

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

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By Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Physiomics Plc Abingdon
| Wiley Online Library Verified
What is the current knowledge on the topic? ○ Oncolytic viruses (OVs) have the potential to sensitize tumors to immune checkpoint blockade, potentially increasing patient response rate. The combination of an OV with an immune checkpoint blocker is currently being studied in clinical trials using a sequential administration strategy. However, their interaction potential is not fully understood and has not been investigated quantitatively by mechanistic modeling. What question did this study address?
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