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Pia Pernille Søgaard on Muck Rack

Pia Pernille Søgaard

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Articles

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin - Nature Communications

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By Qi Tang, Hassan Fakih, Vignesh Hariharan, Ashley Summers, Ken Okamura, Kathryn R. Monopoli, David Cooper Verified, Karen Dresser, Annabelle Biscans, Nazgol-Sadat Haddadi, Ümmügülsüm Yıldız-Altay, Carine Blanchard, Julia Alterman, Anastasia Khvorova, Pia Pernille Søgaard, Malene Jackerott, Nicholas McHugh, Raymond C. Furgal, Jane Chuprin, Adam Clauss
| Nature Verified
Abstract Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors show distinct efficacy and safety profiles, likely reflecting variable selectivity for JAK subtypes. Absolute JAK subtype selectivity has not yet been achieved.
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