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Piaoran Zhang

As seen in: Nature
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Articles

A phage-encoded sponge protein suppresses bacterial TIR-Caspase immune signaling

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By Yu Chen, Linlin Wei, Zhenhao Han, Ruiliang Zhao, Zhifeng Zeng, Yanqiu Liu, Yue Fan, Long Sheng, Hao Wang, Rafael Pinilla-Redondo, Yue Feng, Wenyuan Han, Piaoran Zhang, Keyi Tan
| Nature Verified
Abstract Triggering immune response through generation of signal molecules is a common immune strategy across all domains of life. In the bacterial type IV Thoeris anti-phage system, a Toll/interleukin-1 receptor (TIR)-domain protein produces adenosine 5’-diphosphate-cyclo[N7:1”]-ribose (N7-cADPR) as the immune signal to activate a Caspase-like effector.
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