Pierre Barraud

Article Dans Une Revue (Article De Synthèse) Genes Année : 2024 Beyond the Anticodon: tRNA Core Modifications and Their Impact on Structure, Translation and Stress Adaptation Mots clés transfer RNAs post-transcriptional modifications tRNA modifications tRNA stability modification circuits translation stress response bacteria yeast Origine Fichiers éditeurs autorisés sur une archive ouverte hal-04620528 , version 1 (21-06-2024) Marcel-Joseph Yared, Agathe Marcelot, Pierre Barraud.

Abstract The human mitochondrial genome is transcribed into two RNAs, containing mRNAs, rRNAs and tRNAs, all dedicated to produce essential proteins of the respiratory chain. The precise excision of tRNAs by the mitochondrial endoribonucleases (mt-RNase), P and Z, releases all RNA species from the two RNA transcripts. The tRNAs then undergo 3′-CCA addition. In metazoan mitochondria, RNase P is a multi-enzyme assembly that comprises the endoribonuclease PRORP and a tRNA methyltransferase subcomplex.

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