Skip To Main Content
Pim-Bart Feijens on Muck Rack

Pim-Bart Feijens

Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Pim-Bart

Contact Pim-Bart, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense

|
By Daniel Silva, Pim-Bart Feijens, Rik Hendrickx, An Matheeussen
| Wiley Online Library Verified
Abstract This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure-activity relationships of various aromatic ring substitutions. The compounds were evaluated in an integrated in vitro screen. Eight compounds exhibited selective activity against T. b. rhodesiense (IC50<2.2 μm) with no detectable side activity against T. cruzi and Leishmania infantum. Compound 20 showed low nanomolar potency against T. b.
Open in Who Shared Issue with article?
See all 1 articles