Pim-Bart Feijens on Muck Rack

Pim-Bart Feijens

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Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense

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By Daniel Silva, Pim-Bart Feijens, Rik Hendrickx, An Matheeussen
| Wiley Online Library
Abstract This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure-activity relationships of various aromatic ring substitutions. The compounds were evaluated in an integrated in vitro screen. Eight compounds exhibited selective activity against T. b. rhodesiense (IC50<2.2 μm) with no detectable side activity against T. cruzi and Leishmania infantum. Compound 20 showed low nanomolar potency against T. b.
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