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Abstract Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure, yet early pathways linking hepatocellular stress to tissue integrity remain incompletely defined. Here, we demonstrate that canonical Hh signaling is rapidly activated in centrilobular hepatocytes upon APAP challenge, preceding significant inflammation and recovery.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
