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Fabrication of human serum albumin–imprinted photothermal nanoparticle for enhanced immunotherapy Jizhuang Ma, Yao Zhang, Hongyi Sun, Pingtian Ding and Da-Wei Chen Abstract Photothermal nanoparticles have been confirmed to induce antitumor immune response and turn “cold tumor” into “hot tumor”. However, their delivery efficacy to tumors is limited by the elimination from the reticalendothel system.
Polymers, as widely used non-viral gene carriers, are suffered from high cytotoxicity and relatively low transfection efficiency. Such crucial drawbacks of polymers could be solved by incorporating short and bioactive peptides. The resulted synthetic polymer-peptide conjugates can not only maintain their own special characteristics, but also gain novel characteristics far beyond their parent polymer and peptide components to overcome barriers of gene delivery.
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