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Piotr Jung

As seen in: BioRxiv, Cell Press
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Articles by Piotr Jung

PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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By Byrne C.J, Tamara Chessa, Piotr Jung, Sabine Suire
| Cell Press Verified
Highlights • In healthy tissue, IRS signaling and negative feedback set PI3K pathway activity • Loss of PTEN leads to the adaptor PLEKHS1 becoming the main driver of PI3Ks • The switch results in part from negative feedback suppressing IRS activation of PI3Ks • PLEKHS1 evades negative feedback and is YXXM-phosphorylated by a PIP3-dependent mechanism Summary The PIP3/PI3K network is a central regulator of metabolism and is frequently activated in cancer, commonly by loss of the PIP3/PI(3,4)P2...
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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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By Sabine Suire, Karen Anderson, Piotr Jung, Arqum Anwar
| BioRxiv
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