Piotr Kopec on Muck Rack

Piotr Kopec

As seen in: Nature
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Articles

Targeted blocking of gene splicing can dysregulate intron-embedded primary microRNAs - Communications Biology

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By Hasan Ali, Athul R. Ramesh, Naveen Nedunchezhian, Wojciech Kwiatkowski, Piotr Kopec, Natalia Kowalewska, Barbara Gnutti, Dario Finazzi, Savani Anbalagan
| Nature
Abstract Addressing whether antisense oligonucleotides (ASOs)-based targeting of genes embedded with intronic noncoding RNAs (ncRNAs) affects the expression and function of intronic ncRNAs is crucial to the success of ASOs in clinical trials. While studying zebrafish posterior pituitary development—an important neuroendocrine interface—we found that an ASO targeting the slit3 splice site, but not the translation start site, disrupts pituitary axonal morphogenesis.
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Targeted blocking of gene splicing can dysregulate intron-embedded microRNAs

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By Hasan Ali, Wojciech Kwiatkowski, Piotr Kopec, Naveen Nedunchezhian
| biorxiv.org
Abstract ASOs (antisense oligonucleotides) are a promising therapeutic approach for suppression, induction of gene expression or the correction of aberrant splicing. Addressing whether ASOs targeting genes embedded with intronic noncoding RNAs (ncRNAs) affect the expression and function of intronic ncRNAs is of importance to the success of ASOs in clinical trials.
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