Piro Siuti

Molecular glues stabilize interactions between E3 ligases and novel substrates to promote substrate degradation, thereby facilitating the inhibition of traditionally “undruggable” protein targets. However, most known molecular glues have been discovered fortuitously or are based on well-established chemical scaffolds. Efficient approaches for discovering and characterizing the effects of molecular glues on protein interactions are required to accelerate the discovery of novel agents.

Circuit scrambling Circuit scrambling is an approach to encrypt the topology of a genetic circuit, either in vitro or in vivo (i.e., within an engineered cell), which would offer protection when the circuit is being stored or transferred between parties. Circuit scrambling can be achieved through the use of site-specific uni-directional recombinases, such as large serine recombinases, that recognize specific DNA sequences known as attB and attP sites5.