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From extracellular entry to intracellular release: A water-assisted transport cycle for creatine in SLC6A8
1 INTRODUCTION Solute carriers (SLCs) form the largest family of secondary active transporters in the human genome, with over 400 members organized into 65 families. These transporters facilitate the transmembrane uptake and exchange of various solutes, including inorganic ions, amino acids, sugars, lipids, neurotransmitters, and drugs (He et al., 2009; Hediger et al., 2004; Liu, 2019).
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