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Piyao Ji

As seen in: Nature, MDPI
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Articles

cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis

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By Yantao Zhang, Zhenxing Zhu, Piyao Ji, Jianghua Ming, Yan Zhou
| Nature Verified
Abstract Mitochondrial dysfunction-driven senescence is a central mechanism in the development of osteoarthritis (OA). Leucine-rich repeat kinase 2 (LRRK2), a multifunctional kinase implicated in maintaining mitochondrial homeostasis, has been examined in several inflammatory conditions. However, its role in regulating cellular senescence and its pathogenic contribution to OA remain insufficiently understood.
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Connection between Osteoarthritis and Nitric Oxide: From Pathophysiology to Therapeutic Target

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By Huanyu Jiang, Yan Zhou, Piyao Ji, Xiaobin Shang
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Huanyu Jiang 1,2, Piyao Ji 1,2, Xiaobin Shang 1 and Yan Zhou 1,2,* 1 Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, China 2 Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China * Author to whom correspondence should be addressed.
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