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Png Loke

As seen in: Nature, The Journal of Immunology
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Articles

NF-κB subunits direct kinetically distinct transcriptional cascades in antigen receptor-activated B cells - Nature Immunology

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By Mingming Zhao, Prashant Chauhan, Amit Singh, Mary Kaileh, Hongkai Ji, Satabdi Nandi, Supriyo De, Png Loke, Weiqiang Zhou, Cheryl A. Sherman, Jaimy Joy
| Nature Verified
Mice, B cell preparation, cell culture and antibodies Primary B cells were purified from the spleens of 6- to 12-week-old WT (C57BL/6), RelAfl/fl (ref. 51), RelA cKO (RelAfl/flxCd19-cre; generated by crossing RelAfl/fl with Cd19-cre (Jackson Laboratory, 006785)) and Rel KO (Rel−/−) (ref. 17). For each experiment, five to six age-matched mice (mixed male/female) were used.
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Role of retinoic acid in diet induced obesity

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By Uma Mahesh Gundra, Jordan Poles, Png Loke
| The Journal of Immunology Verified
Obesity is a complex disease associated with chronic, low-grade inflammation of the adipose tissue, which promotes insulin resistance and type-2 diabetes. Adipose tissue macrophages (ATMs) with an inflammatory M1 profile are involved in the development and progression of obesity associated metabolic diseases.
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