Po-Jui Lu

Introduction Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system, manifesting clinically by acute episodes of inflammatory activity (relapses) and continuous deterioration of neurological functions.

Assessing the existence and extent of spontaneous or therapy-promoted reparative activity in multiple sclerosis (MS) patients is one of the main challenges in people suffering from this disease.1, 2 MS pathology is characterized by focal and diffuse inflammation and degeneration in both white matter (WM) and grey matter (GM), which—to a variable extent—are countered by remyelination, axon remodeling, oligodendrocyte, and glial cell activity (here, referred to as “reparative processes” or...

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