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Poggi Longostrevi on Muck Rack

Poggi Longostrevi

As seen in: Frontiers in Immunology
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Articles

GD2-targeted immunotherapy in pediatric bone sarcomas: a systematic review of emerging strategies and combination approaches

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By Poggi Longostrevi, Maria Grazia, Sebastian Dorin
| Frontiers in Immunology
Abstract Introduction: Primary bone sarcomas, including Osteosarcoma (OS) and Ewing sarcoma (ES), are rare pediatric malignancies with limited therapeutic advances over recent decades and poor outcomes, especially for patients with metastatic and refractory/relapsed disease. Disialoganglioside 2 (GD2) has emerged as a promising immunotherapeutic target due to its high expression in pediatric bone sarcomas and its role in tumor progression and treatment resistance.
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