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Poh Yin on Muck Rack

Poh Yin

As seen in: Frontiers, Cancer Research
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Articles

One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication

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By Poh Yin
| Cancer Research Verified
To achieve eradication of solid tumors, we examined how many neoantigens need to be targeted with how many T-cell receptors (TCR) by which type of T cells. Unmanipulated, naturally expressed (autochthonous) neoantigens were targeted with adoptively transferred TCR-engineered autologous T cells (TCR-therapy).
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One CD4+TCR and one CD8+TCR targeting autochthonous neoantigens are essential and sufficient for tumor eradication

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By Poh Yin
| Cancer Research Verified
Purpose: To achieve eradication of solid tumors, we examined how many neoantigens need to be targeted with how many TCRs by which type of T cells. Experimental Design: Unmanipulated, naturally expressed (autochthonous) neoantigens were targeted with adoptively transferred TCR-engineered autologous T cells (TCR-therapy).
Open in Who Shared View Duplicates (2) Issue with article?

Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine

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By Stephen Ferris, Yifan Zhan, Melanie Grant, Poh Yin
| Frontiers
Introduction Tumor-specific antigens recognized by the T-cell receptors of cytotoxic T lymphocytes (CTLs) are antigen epitopes bound to human leukocyte antigen (HLA) class I on the surface of tumor cells and are usually short peptides 8–11 amino acids in length (1, 2).
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