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As seen in: The Journal of Immunology
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Articles

Ptk7-Deficient Mice Have Decreased Hematopoietic Stem Cell Pools as a Result of Deregulated Proliferation and Migration

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By Marie-Laure Arcangeli, Maria De Grandis, Anne-Catherine Lhoumeau, Polarité Cellulaire, Marilyn Giordano
| The Journal of Immunology Verified
Hematopoietic stem cells (HSCs) located in adult bone marrow or fetal liver in mammals produce all cells from the blood system. At the top of the hierarchy are long-term HSCs endowed with lifelong self-renewal and differentiation properties. These features are controlled through key microenvironmental cues and regulatory pathways, such as Wnt signaling.
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