Poorani Ganesh on Muck Rack

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Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice

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By Biodata Mining, Skin Diseases, Michael R.F, Poorani Ganesh
| rupress.org
We show that PRMT1 is a determinant of activated and GCBC fate that is necessary to promote antibody affinity maturation. Our data are consistent with previous reports showing that PRMT1, while necessary for B cell development, is dispensable for follicular B cells, yet required for MZB cell homeostasis and GC formation (Dolezal et al., 2017; Hata et al., 2016; Infantino et al., 2017). However, the mouse models used so far were not adequate for probing the functions of PRMT1 in GCBC.
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