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Pouria Akhbari

As seen in: Science Magazine
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Articles

Small things matter: Lack of extraislet β cells in type 1 diabetes

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By Zechuan Shi, Katarzyna J. Radomska, Huayong Xie, Kathryn Murrall, Christiana Lekka, Christine S Flaxman, Rebecca Wyatt, Pouria Akhbari, Irina Kusmartseva, Stephanie Hunter, Pia Leete, Noel Morgan, Sarah Richards, Kathryn Murrall, Teifion Luckett, Isabel Burn, Elena Osokina
| Science Magazine Verified
Abstract Recent three-dimensional (3D) analyses reported an abundance of small β cell–rich endocrine objects (EOs) in the human pancreas. Here, we used archival, immunolabeled 2D pancreas sections to assess morphological EO parameters in donors with or without type 1 diabetes (T1D), varying in age and disease duration. We confirm that abundant small, insulin-positive EOs are present in donors without diabetes and comprise most of the pancreatic endocrine area in early life.
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Temporal regulation of interferon signalling in human EndoC-βH1 cells

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By Shalinee Dhayal, Kaiyven Afi Leslie, Mohammad Baity, Pouria Akhbari
Abstract During the development of type 1 diabetes, interferons (IFN) are elaborated from islet-infiltrating immune cells and/or from virally infected β-cells. They act via specific receptors to increase, acutely, the phosphorylation of the transcription factors STAT1 and 2. However, the longer-term impacts of chronic IFN stimulation are poorly understood and were investigated in the current study.
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