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Prabodh Chander Sharma on Muck Rack

Prabodh Chander Sharma

As seen in: Taylor & Francis Online
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Articles

In silico investigation of novel isatin derivatives as potential multi-target anticancer agents targeting VEGFR-2, EGFR, and caspase-6

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By Vipul Kumar, Vivek Kumar Verified, Prabodh Chander Sharma
| Taylor & Francis Online
Abstract The isatin scaffold has emerged as a promising platform for the development of anticancer agents, as evidenced by several clinically relevant isatin-based compounds. In this study, 85 novel isatin derivatives were designed based on literature reports and evaluated using drug-likeness prediction, ADME profiling, molecular docking, and molecular dynamics simulations. The compounds were screened against VEGFR-2, EGFR, and caspase-6 to identify potential multi-target lead candidates.
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