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Prachi Umbarkar on Muck Rack

Prachi Umbarkar

As seen in: Nature, International Journal of Cardiology
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Articles

Osimertinib-induced cardiotoxicity is driven by HDAC-dependent epigenetic repression and rescued by vorinostat

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By Angelica Corà, Allen Sam Titus, Ashish Jaiswal, Baldeep Singh, Prachi Umbarkar, Daniel Li, Roshan Kumar Dutta, Qinkun Zhang, Suresh K Verma, Hind Lal, Arvind Singh Bhati
| Nature Verified
Abstract Osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), has improved outcomes in non-small cell lung cancer (NSCLC) patients harboring the T790M mutation; however, emerging clinical evidence indicates a risk of cardiotoxicity. Here, we establish the first in vivo preclinical model of osimertinib-induced cardiotoxicity using transverse aortic constriction (TAC) in mice.
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ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway

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By Shanghai Jiao Tong, Francisco C Villafuerte, Jianyun Yan, Prachi Umbarkar
Introduction Heart failure is an increasingly concerning public health problem with alarming morbidity and mortality, and cardiac fibrosis remains the main pathological outcome of heart failure (1). The prominent features of cardiac fibrosis are excessive remodeling and accumulation of extracellular matrix (ECM) (2). Replacement fibrosis in research animal models is typically established by myocardial infarction and the reactive fibrosis is induced by the pressure load model (3).
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Cardiotoxicity of the BCR-ABL1 tyrosine kinase inhibitors: Emphasis on ponatinib

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By Anand Prakash Singh, Hind Lal, Prachi Umbarkar
| International Journal of Cardiology Verified
Siegel R.L. Miller K.D. Jemal A. Cancer statistics, 2017. CA Cancer J. Clin. 2017; 67: 7-30 Siegel R.L. Miller K.D. Jemal A. Cancer statistics, 2015. CA Cancer J. Clin. 2015; 65: 5-29 Sharma A. Wu J.C. Wu S.M. Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening. Stem Cell Res Ther. 2013; 4: 150 Society A.C. Cancer Facts & Figures 2020. Atlanta, American Cancer Society2020 Shtivelman E. Lifshitz B. Gale R.P. Canaani E.
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